after 19 months, 68,777 persons completed a FOBT, 2,559 were positive and 1,705 colonoscopies were recorded : 605 were normal and 397 yielded small polyps. 366 (36.6%) EGD were performed, 305 in persons with normal colonoscopy and 61 with small polyps. 80 persons (21.9%) had significant abnormal upper gastrointestinal findings : 1 esophageal adenocarcinoma pT1, 3 Barrett's esophagus, 28 grade 1 and 5 grade 2 erosive esophagitis, 26 erosive gastritis, 1 gastric ulcer, 12 gastric polyps (none were adenomas), 2 gastric angiodysplasia, 5 erosive duodenitis and 2 duodenal ulcers. 18 of these lesions were H. pylori positive. The diagnostic yield was significantly greater in men (27.6%) than in women (17.7%)(p=0.02) and in persons with upper gastrointestinal symptoms (37.2%) than in persons without (15%)(p<0.01). Age, the presence of a documented anemia and the use of aspirin or NSAIDs were not significantly associated with abnormal findings. EGD prompted a change in clinical management in 50 persons(15%) : surgical treatment in 1, Argon plasma coagulation in 1, endoscopic follow-up in 3, antipeptic therapy in 46, eradication of H. pylori in 18 and discontinuation of NSAIDs in 4. The impact on clinical management was significantly greater in persons with symptoms (25.6%) than in persons without (10.8%)(p<0.01). The esophageal adenocarcinoma was diagnosed in a symptomatic 66 years old man. Clinically important lesions were diagnosed in only 3.3% of 213 asymptomatic persons. In this group, the number needed to screen with EGD in order to detect one clinically important lesion was 30. One minor dental complication was recorded.