87,790 people (46.6%) completed a FOBT and 18,995 (10.1%) were excluded for recent CRC screening, high risk of CRC or concurrent severe disease, so that adjusted participation rate was 51.8%. Participation was higher in women (54.2%) than in men (49.4%)(p<0.001) and ranged from 45.4% to 59.8% according to districts. Participation was lower below 60 years (47.5%) than after (56.6%). FOBT positivity rate was 3.3%, higher in men (3.9%) than in women (2.8%)(p<0.001). To date 2,408 colonoscopies were performed. The positive predictive value was 10% for CRC (women 7.2%, men 12.5%), 20.8% for advanced adenomas (women 13.4%, men 26.9%) and 42.2% for neoplasia (women 30.6%, men 51.8%). Detection rates for neoplasia and CRC were 11.6 and 2.8 per 1,000 people screened. 27.2% of CRC were in situ, 50% of invasive CRC were stage I and 23.4% stage II. The rate of proximal advanced neoplasia increased with age (16.5% below 65 years, 25.4% after) but didn?t differ with gender. Flexible sigmoidoscopy alone would have missed 21.4% of people with advanced neoplasia, without significant difference according to age and gender. The overall cost of this biennial screening program (without the fees related to colonoscopies) was $2.7 million: fixed cost was $1.88 million ($5 per year per eligible person) and variable cost $0.82 million ($4 per screened person). The cost per screened person was $30 and the cost to find an early-stage neoplasia (advanced adenoma or in situ CRC or stage I CRC) was $4,300.