after 14 months, 1933 FOBT were positive and 916 colonoscopic procedures were recorded : 462 were normal and 202 yielded small polyps. 237 EGD were performed in 92 men and 145 women, 203 with normal colonoscopy and 34 with small polyps. 55 persons (23.2%) had significant abnormal upper gastrointestinal findings : 1 esophageal adenocarcinoma pT1, 3 Barrett's esophagus, 21 grade 1 and 2 grade 2 erosive esophagitis, 22 erosive gastritis, 8 gastric polyps (none were adenomas), 1 gastric angiodysplasia, 2 erosive duodenitis and 2 duodenal ulcers. 10 of these lesions were H. pylori positive. The diagnostic yield was significantly greater in men (31.5%) than in women (17.9%)(p<0.02) and in persons with upper gastrointestinal symptoms (37.8%) than in persons without (18.5%)(p<0.01). Age, anemia and aspirin or NSAID use were not significantly associated with abnormal findings. EGD led to a change in clinical management in 35 persons (14.8%) : surgical treatment in 1, endoscopic surveillance in 3, antipeptic therapy in 27, eradication of H. pylori in 10 and discontinuation of NSAID in 4. The impact on clinical management was significantly greater in persons with symptoms (27.3%) than in persons without (12.3%)(p=0.02). The esophageal adenocarcinoma was diagnosed in a symptomatic 66 years old man. Only one clinically important lesion was diagnosed in 130 asymptomatic persons. One minor dental complication was recorded.